The Alkylating Agent Methyl Methanesulfonate Triggers Lipid Alterations at the Inner Nuclear Membrane That Are Independent from Its DNA-Damaging Ability

In order to tackle the study of DNA repair pathways, physical and chemical agents creating damage, genotoxins, are frequently employed. Despite their utility, effects rarely restricted DNA, therefore simultaneously harm other cell biomolecules. Methyl methanesulfonate (MMS) is an alkylating agent that acts on by preferentially methylating guanine adenine bases. It broadly used both in basic genome stability research as a model for mechanistic studies understand how work, such those chemotherapy. Nevertheless, MMS exerts additional actions, oxidation acetylation proteins. this we introduce important notion also triggers lipid stress stems from affects inner nuclear membrane. The membrane plays essential role virtually all maintenance pathways. Thus, want raise awareness relative contribution genotoxic stresses when using may be difficult dissect will matter conclusions drawn studies.